A fixed-dose combination of an essential mineral supplement (Calcium Lactate) and a first-generation sedating antihistamine (Luvistin, generic name: Clemastine). It is primarily indicated for the symptomatic relief of allergic conditions like urticaria and allergic rhinitis, while simultaneously addressing potential calcium deficiency, a common comorbidity in the Indian population due to dietary habits and limited sun exposure.
Adult: One tablet twice daily, or as directed by the physician. Typically 1-2 tablets per day in divided doses.
Note: Take after food to minimize gastric irritation from Calcium and to enhance its absorption. Swallow whole with a full glass of water. Do not crush or chew. Avoid taking within 2 hours of other medications (especially tetracyclines, bisphosphonates, levothyroxine) or iron supplements.
Clemastine is a potent, competitive, reversible antagonist of histamine at the H1-receptor. It inhibits the vasodilatory, pruritic, and bronchoconstrictor effects of histamine. Calcium Lactate provides bioavailable calcium ions, essential for neuromuscular function, blood coagulation, and bone mineralization.
Pregnancy: Category B (Clemastine). Use only if clearly needed. Avoid in third trimester due to risk of neonatal anticholinergic effects. Calcium requirements increase in pregnancy (1000-1300 mg/day), but supplementation should be managed separately.
Driving: STRONGLY DISCOURAGED. Clemastine causes significant drowsiness and impairs cognitive and motor functions. Do not operate machinery.
| CNS Depressants (Alcohol, Benzodiazepines, Opioids) | Potentiated sedation, respiratory depression, impaired motor skills. | Major |
| Anticholinergics (Atropine, TCAs, Antipsychotics) | Additive anticholinergic effects (dry mouth, urinary retention, constipation, confusion). | Major |
| MAO Inhibitors (Phenelzine, Tranylcypromine) | Exaggerated anticholinergic and CNS depressant effects. | Contraindicated |
| Digoxin | Hypercalcemia may precipitate digitalis toxicity (arrhythmias). | Major |
| Thiazide Diuretics | Increased risk of hypercalcemia due to reduced renal calcium excretion. | Moderate |
| Tetracycline/Quinolone Antibiotics, Bisphosphonates, Levothyroxine | Calcium binds to these drugs, significantly reducing their absorption. | Major |
Same composition (Calcium Lactate (200mg) + Luvistin (20mg)), different brands: