Hepazine

Tricholine Citrate (500mg)
Price: ₹75 - ₹140 for 10 tablets strip
Mfr: Alkem Laboratories Ltd. | Form: Tablet

📋 Clinical Overview

Tricholine Citrate is a choline-containing compound used primarily as a lipotropic agent and hepatoprotective. It acts as a source of choline, an essential nutrient involved in fat metabolism and liver function. In the Indian context, it is widely prescribed for fatty liver disease, dyspepsia, and as an adjunct in hyperlipidemia management.

💊 Dosage & Administration

Adult: 500mg to 1.5g (1 to 3 tablets of 500mg) per day, in divided doses, after meals. Typical: 500mg two to three times daily.

Note: Tablet to be taken after meals with a full glass of water. Do not crush or chew unless instructed. For syrup formulations, use the measuring cup provided.

⚠️ Contraindications

  • Hypersensitivity to Tricholine Citrate or any component.

🔬 Mechanism of Action

Provides choline, a methyl donor and essential component of phosphatidylcholine (lecithin). This aids in: 1) Hepatic fat metabolism - promotes synthesis of lipoproteins for fat transport out of the liver, reducing hepatic steatosis. 2) Bile secretion - choline is necessary for bile production, improving fat emulsification and digestion. 3) Membrane integrity - as a phospholipid precursor, it helps maintain hepatocyte membrane structure.

🤕 Side Effects

  • Nausea
  • Diarrhea or loose stools
  • Abdominal discomfort

🤰 Special Populations

Pregnancy: Category A (Indian classification). Considered safe. Choline is an essential nutrient for fetal brain development. Use as per physician advice.

Driving: Unlikely to affect ability. Dizziness is a rare side effect.

🔄 Drug Interactions

MethotrexateCholine may reduce hepatotoxicity of methotrexate (beneficial interaction).Moderate
Anticoagulants (Warfarin)Theoretical interaction due to potential effects on lipid metabolism; monitor INR.Low
Anticholinergic drugs (e.g., Atropine)Choline is a precursor to acetylcholine; may theoretically counteract anticholinergic effects.Low
LevodopaHigh choline may reduce efficacy in Parkinson's disease; separate administration.Moderate

🔁 Alternatives to Hepazine

Same composition (Tricholine Citrate (500mg)), different brands:

Cytoride Tridoss Choliv Colicol