A parenteral nutritional supplement combining a concentrated, hydrolyzed extract of porcine or bovine liver with Thiamine Hydrochloride (Vitamin B1). The liver extract provides a rich source of essential amino acids, peptides, nucleotides, and other hepatotrophic factors, while thiamine acts as a critical coenzyme in carbohydrate metabolism. It is primarily used as a hepatoprotective and restorative agent, as well as for nutritional support in conditions of deficiency and convalescence.
Adult: 1 ml to 2 ml by intramuscular injection, once daily or on alternate days, as directed by the physician. Deep IM injection into the gluteal muscle is standard.
Note: For intramuscular use only (unless specified for IV by a specialist). Use a deep IM injection, preferably in the upper outer quadrant of the gluteus maximus. Rotate injection sites. Aspirate before injection to avoid intravascular administration. Do not mix with other injections in the same syringe. The solution should be clear; do not use if cloudy or precipitated.
The combination exerts a dual mechanism: 1) **Liver Extract**: Provides pre-digested proteins, essential amino acids (like methionine, cysteine), peptides, choline, inositol, and anti-fatty liver factors. These serve as building blocks for hepatic regeneration, promote protein synthesis in hepatocytes, and may have lipotropic effects (preventing/ reducing fatty infiltration of the liver). 2) **Thiamine (Vitamin B1)**: As thiamine pyrophosphate (TPP), it acts as an essential coenzyme for key reactions in carbohydrate metabolism (pyruvate dehydrogenase, transketolase, alpha-ketoglutarate dehydrogenase complexes), crucial for energy production in all cells, including hepatocytes.
Pregnancy: Category C: Animal reproduction studies have not been conducted. Use only if the potential benefit justifies the potential risk to the fetus. Liver extract is of animal origin.
Driving: Unlikely to affect ability to drive or use machines. However, dizziness has been reported rarely.
| Neuromuscular Blocking Agents (e.g., Succinylcholine) | Thiamine may potentiate the action of these agents. | Moderate |
| Loop Diuretics (e.g., Furosemide) | May increase renal excretion of thiamine, potentially reducing its efficacy. | Moderate |
| Alcohol (Chronic use) | Impairs thiamine absorption and utilization, increasing requirement. This is a key indication for the combination. | Major |