A fixed-dose combination of essential fatty acids (GLA from Evening Primrose Oil) and a potent antioxidant (Vitamin E as Tocoferol). Evening Primrose Oil (EPO) is derived from the seeds of Oenothera biennis, providing gamma-linolenic acid (GLA), a precursor for prostaglandin E1 synthesis. Tocoferol (Vitamin E) acts as a lipid-soluble antioxidant, protecting cell membranes from oxidative damage. This combination is primarily used for its anti-inflammatory, hormonal modulating, and skin-barrier enhancing properties, widely utilized in dermatological, gynecological, and metabolic conditions in the Indian context.
Adult: One softgel capsule (containing EPO 500mg + Tocoferol 30mg) orally, twice daily with meals. For cyclical mastalgia/PMS: Start 10 days before expected menses and continue through cycle, or continuously.
Note: Must be taken with or immediately after a meal containing fats (e.g., milk, curd, nuts, oil) to enhance absorption. Swallow the softgel whole with a glass of water. Do not crush or chew. Best taken at consistent times daily.
The combination works synergistically. EPO provides GLA (omega-6), which is converted to DGLA. DGLA is a substrate for cyclooxygenase, yielding anti-inflammatory prostaglandin E1 (PGE1), which inhibits platelet aggregation, causes vasodilation, and modulates immune response. It also competes with arachidonic acid for metabolism, reducing pro-inflammatory series-2 prostaglandins and leukotrienes. Tocoferol (Vitamin E) interrupts the chain reaction of lipid peroxidation in cell membranes by scavenging peroxyl radicals, protecting GLA and other PUFAs from oxidative degradation, thereby potentiating EPO's action.
Pregnancy: Category N (Not classified by US FDA). Generally considered safe in recommended dietary amounts. However, pharmacological doses (especially high-dose EPO) are not recommended due to theoretical risk of uterine stimulation and prolonged gestation. Use only if clearly needed and under obstetrician guidance.
Driving: No known effects on driving ability.
| Warfarin, Acenocoumarol, Clopidogrel, Aspirin | Increased risk of bleeding due to antiplatelet effects of GLA (PGE1) and potential Vitamin K antagonism by high-dose Vitamin E. | Major |
| Phenothiazines (e.g., Chlorpromazine) & Other Antipsychotics | EPO may lower seizure threshold, potentially counteracting anticonvulsant effects and increasing risk of seizures. | Moderate |
| Cyclosporine | Vitamin E may increase absorption and blood levels of Cyclosporine, increasing risk of nephrotoxicity. | Moderate |
| Simvastatin, Atorvastatin (Statins) | Vitamin E may blunt the rise in HDL cholesterol induced by some statins. No significant effect on LDL lowering. | Minor |
| Chemotherapy/Radiotherapy | Antioxidants like Vitamin E may theoretically interfere with oxidative mechanisms of some therapies. Controversial; consult oncologist. | Moderate |
Same composition (Evening Primrose Oil (500mg) + Tocoferol (30mg)), different brands: