A topical antifungal combination used primarily for the treatment of superficial fungal infections. Amorolfine is a morpholine derivative antifungal with broad-spectrum fungicidal and fungistatic activity. Phenoxyethanol acts as a preservative and has mild antiseptic properties, enhancing the formulation's stability and providing a secondary antimicrobial effect against bacteria and fungi.
Adult: Apply a thin layer once daily to the affected skin and surrounding area. Duration: Tinea corporis/cruris: 2-3 weeks. Tinea pedis: 4-6 weeks. Pityriasis versicolor: 2-3 weeks.
Note: 1. Clean and dry the affected area thoroughly. 2. Apply a thin layer and rub gently. 3. Wash hands after application unless hands are being treated. 4. Do not cover with occlusive dressings unless advised by a doctor. 5. Continue use for the full prescribed duration, even if symptoms improve earlier.
Amorolfine exerts its antifungal effect by a dual mechanism: 1) Inhibition of delta-14-reductase and delta-7-delta-8 isomerase in the ergosterol biosynthesis pathway. This leads to depletion of ergosterol (an essential component of fungal cell membranes) and accumulation of toxic sterol intermediates. 2) Direct membrane damage due to altered sterol composition. Phenoxyethanol disrupts bacterial and fungal cell membranes and inhibits cellular enzymes.
Pregnancy: Category B (US FDA). Animal studies show no risk, but human data is limited. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus, especially in the first trimester. Topical application minimizes systemic exposure.
Driving: No effect on ability to drive or use machines.
| No specific data available. Consult doctor. |