Serratiopeptidase is a proteolytic enzyme derived from the enterobacterium *Serratia marcescens* (formerly *Serratia E15*). It is a potent anti-inflammatory, anti-edemic, and fibrinolytic agent widely used in India for managing pain and inflammation associated with various surgical and inflammatory conditions. It works by breaking down non-living tissue, exudates, and blood clots without affecting living cells.
Adult: 10 mg three times daily. In acute conditions, can be initiated at 10 mg three times a day, then reduced to 10 mg twice daily as symptoms improve.
Note: Must be taken on an EMPTY STOMACH, at least 1 hour before or 2 hours after meals, with a full glass of water. Do NOT crush, chew, or break the enteric-coated tablet. Swallow whole.
Serratiopeptidase exerts its effects through proteolytic (protein-digesting) activity. It selectively hydrolyzes (breaks down) abnormal exudates such as fibrin, fibrinogen, and other denatured proteins found in inflammatory sites, blood clots, and mucous secretions. This reduces edema, improves microcirculation, and facilitates tissue repair. It also modulates inflammatory cytokines (e.g., bradykinin) and enhances the penetration of antibiotics into tissues.
Pregnancy: Category C: Animal reproduction studies have not been conducted. Not recommended during pregnancy unless the potential benefit justifies the potential risk to the fetus. Use only under strict medical supervision.
Driving: Serratiopeptidase may cause dizziness in some patients. Caution is advised when driving or operating machinery until the patient's response is known.
| Warfarin, Acenocoumarol, Dabigatran, Rivaroxaban, Apixaban | Increased risk of bleeding due to additive fibrinolytic/anti-coagulant effect. | Major |
| Aspirin, Clopidogrel, Ticagrelor, NSAIDs (e.g., Ibuprofen, Diclofenac) | Increased risk of gastrointestinal bleeding and antiplatelet effect. | Major |
| Antibiotics (especially Penicillins, Cephalosporins) | Serratiopeptidase may enhance tissue penetration of antibiotics, potentially improving efficacy. This is often a desired combination. | Moderate |
| Herbal Supplements (Ginkgo biloba, Garlic, Ginseng) | Increased risk of bleeding. | Moderate |
Same composition (Serratiopeptidase (10mg)), different brands: