A multi-component ophthalmic solution combining decongestants, lubricants, and mild antiseptic agents for symptomatic relief of ocular redness, irritation, and minor infections. It is primarily indicated for allergic conjunctivitis, minor eye irritations, and as a lubricant for dry eyes with associated redness. The combination provides rapid vasoconstriction (Naphazoline, Phenylephrine), soothing and cooling relief (Menthol, Camphor), mucoadhesive lubrication (Carboxymethylcellulose), and antimicrobial action (Stabilized Oxychloro complex).
Adult: One to two drops in the affected eye(s) every 4 to 6 hours as needed for symptoms. DO NOT EXCEED 4 INSTILLATIONS PER DAY IN ANY 24-HOUR PERIOD.
Note: 1. Wash hands. 2. Tilt head back. 3. Gently pull lower eyelid down to form a pouch. 4. Instill drop(s) into the pouch without touching the dropper tip to eye, eyelid, or any surface. 5. Close eye gently for 1-2 minutes, applying gentle pressure to the nasolacrimal duct (inner corner of eye) to minimize systemic absorption. 6. Wait at least 15 minutes before inserting contact lenses. Do not use while contact lenses are in the eye.
The combination works through multiple synergistic mechanisms: 1) Naphazoline and Phenylephrine are alpha-1 and alpha-2 adrenergic agonists causing vasoconstriction of conjunctival blood vessels, reducing redness and edema. 2) Carboxymethylcellulose acts as a demulcent and lubricant, stabilizing the tear film and protecting the ocular surface. 3) Menthol and Camphor stimulate TRPM8 cold receptors, providing a cooling, soothing sensation and mild local anesthetic effect. 4) Stabilized Oxychloro complex (Purite) releases hypochlorous acid, a natural oxidant with antimicrobial activity against pathogens, and acts as a preservative.
Pregnancy: Category C (US FDA). No adequate and well-controlled studies in pregnant women. Use only if potential benefit justifies potential risk to the fetus. Systemic absorption of sympathomimetics can cause uterine vasoconstriction. Avoid in first trimester unless absolutely necessary.
Driving: May cause transient blurred vision, dizziness, or mydriasis affecting night vision. Patients should not drive or operate machinery until vision clears and they are sure they are not affected.
| Monoamine Oxidase Inhibitors (MAOIs) - e.g., Phenelzine, Selegiline, Tranylcypromine | Potentiates pressor effects of Phenylephrine/Naphazoline, risk of hypertensive crisis. | Major - CONTRAINDICATED |
| Tricyclic Antidepressants (TCAs) - e.g., Amitriptyline, Imipramine | Potentiates pressor response, increasing risk of hypertension and arrhythmias. | Major |
| Beta-blockers (non-cardioselective) - e.g., Propranolol | Unopposed alpha-adrenergic stimulation can lead to severe hypertension and bradycardia. | Major |
| Other Sympathomimetics (oral or topical) - e.g., Pseudoephedrine, other nasal/ocular decongestants | Additive adrenergic effects, increasing risk of systemic side effects. | Moderate |
| Antihypertensives (e.g., Alpha-blockers, ACE inhibitors) | May antagonize the blood pressure-lowering effect. | Moderate |
| Digitalis Glycosides (e.g., Digoxin) | Increased risk of cardiac arrhythmias. | Moderate |
Same composition (Camphor (0.01% w/v) + Carboxymethylcellulose (0.5% w/v) + Menthol (0.005% w/v) + Naphazoline (0.05% w/v) + Phenylephrine (0.012% w/v) + Stabilized Oxychloro (0.005% w/v)), different brands: