Trypsin Chymotrypsin is a proteolytic enzyme preparation derived from bovine pancreas, standardized to contain 50000 Anti-inflammatory Units (AU). It is a systemic anti-inflammatory, anti-edematous, and fibrinolytic agent used primarily to reduce inflammation, swelling, and pain associated with trauma and post-operative conditions. It works by breaking down necrotic tissue, fibrin clots, and exudates, thereby facilitating healing.
Adult: 1 tablet (50000 AU) three to four times daily. For severe conditions, an initial dose of 2 tablets three times daily for the first 2-3 days may be used, followed by maintenance dose.
Note: To be taken on an empty stomach, at least 1 hour before or 2 hours after meals, with a full glass of water. Do NOT crush, chew, or break the enteric-coated tablet. Swallow whole.
Trypsin and Chymotrypsin are serine endopeptidases that hydrolyze peptide bonds in proteins and polypeptides. Systemically, they reduce inflammation by: 1) Breaking down fibrinogen, fibrin clots, and necrotic tissue, improving microcirculation and reducing edema. 2) Modulating inflammatory cytokines (e.g., reducing TNF-α, IL-6) and promoting the release of anti-inflammatory mediators. 3) Reducing capillary permeability and leukocyte migration to the site of injury. 4) Facilitating the drainage of protein-rich exudates.
Pregnancy: Category B (Animal studies show no risk, but human studies inadequate). Use only if clearly needed and potential benefit justifies potential risk.
Driving: No known effects on driving ability.
| Anticoagulants (Warfarin, Acenocoumarol, Dabigatran, etc.) | May potentiate anticoagulant effect, increasing risk of bleeding. | Major |
| Antiplatelet drugs (Aspirin, Clopidogrel) | Increased risk of bleeding due to additive effects. | Moderate |
| Other Proteolytic Enzymes (Papain, Bromelain) | Additive therapeutic and adverse effects. | Moderate |
| Antibiotics (Tetracyclines, Aminoglycosides) | Theoretical interaction - enzymes may affect absorption. Separate administration by 2-3 hours. | Minor |
Same composition (Trypsin Chymotrypsin (50000AU)), different brands: