A fixed-dose topical combination of a potent corticosteroid (Betamethasone) and an antimicrobial/antifungal agent (Clioquinol). Betamethasone provides potent anti-inflammatory, anti-pruritic, and vasoconstrictive effects, while Clioquinol acts against a broad spectrum of dermatophytes, yeasts (including Candida), and certain bacteria (Gram-positive and Gram-negative). This combination is specifically indicated for inflammatory dermatoses complicated or at high risk of secondary bacterial or fungal infections.
Adult: Apply a thin film to the affected area 2 to 3 times daily. Rub gently until it disappears. Duration should be limited, typically 1-2 weeks for acute conditions. Do not exceed 4 weeks without medical supervision.
Note: Wash and dry the affected area thoroughly before application. Use fingertips to apply a thin layer. Wash hands after application unless hands are being treated. Do not bandage or cover the area unless directed by a physician (occlusion dramatically increases absorption and side effects). Do not use on broken skin or open wounds extensively.
Betamethasone binds to cytoplasmic glucocorticoid receptors, modulating gene transcription. This leads to synthesis of anti-inflammatory proteins (lipocortin) and inhibition of pro-inflammatory mediators (cytokines, leukotrienes, prostaglandins). It also causes vasoconstriction. Clioquinol acts by chelating essential metal ions (e.g., Fe, Cu) required for microbial enzyme function, disrupting mitochondrial respiration and DNA synthesis in fungi and bacteria.
Pregnancy: Category C (US FDA). Topical corticosteroids, especially potent ones, should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Use should be limited in amount and duration. Avoid large areas or long-term use. No adequate and well-controlled studies in pregnant women.
Driving: No effect on driving ability.
| Other Topical Corticosteroids | Additive risk of local and systemic side effects. | Major |
| Topical Retinoids (Tretinoin, Adapalene) | May increase skin irritation and dryness. | Moderate |
| Topical Astringents, Alcohol-based preparations | May increase stinging, burning, and dryness. | Moderate |
| Systemic Corticosteroids (e.g., Prednisolone) | Increased risk of systemic corticosteroid side effects and HPA axis suppression. | Major |
Same composition (Betamethasone (0.1% w/w) + Clioquinol (Iodochlorhydroxyquin) (3% w/w)), different brands: