A high-potency neurotropic B-complex formulation designed for the therapeutic management of severe B-vitamin deficiencies and neuropathic conditions. Thiamine (B1) is essential for carbohydrate metabolism and nerve function. Pyridoxine (B6) acts as a cofactor in amino acid metabolism and neurotransmitter synthesis. Methylcobalamin (B12) is the active form of vitamin B12, crucial for myelin synthesis, hematopoiesis, and neuronal health. This combination is particularly relevant in the Indian context due to the high prevalence of nutritional deficiencies, diabetic neuropathy, and vegetarian/vegan diets leading to B12 deficiency.
Adult: One tablet once daily, or as directed by the physician. Often prescribed for 4-8 weeks initially, then reassessed. For severe deficiency, parenteral therapy may be initiated first.
Note: Take after food to improve tolerance and absorption. Swallow whole with a glass of water. Do not crush or chew. Best taken in the morning to avoid potential sleep disturbances from B6. Consistent daily intake is key.
The combination acts synergistically to support neuronal metabolism, repair, and function. Thiamine (as TPP) is a coenzyme for pyruvate dehydrogenase and transketolase in the Krebs cycle and pentose phosphate pathway, crucial for ATP production in neurons. Pyridoxine (as PLP) is a cofactor for over 100 enzymes involved in neurotransmitter synthesis (GABA, serotonin, dopamine) and homocysteine metabolism. Methylcobalamin is a cofactor for methionine synthase (converting homocysteine to methionine) and L-methylmalonyl-CoA mutase. It is essential for myelin synthesis and maintenance, and for neuronal methylation reactions.
Pregnancy: Category A (US FDA). Considered safe. Required for fetal development. Dose should not exceed RDA unless treating a documented deficiency. High-dose Pyridoxine is used for nausea but prolonged mega-doses should be avoided.
Driving: No known effects. However, if dizziness or somnolence occurs as a rare side effect, caution is advised.
| Levodopa | Pyridoxine (>5 mg) increases peripheral decarboxylation of levodopa, reducing its central efficacy for Parkinson's disease. | Major |
| Phenobarbitone / Phenytoin | Pyridoxine may decrease serum levels of these anticonvulsants. | Moderate |
| Isoniazid, Cycloserine, Penicillamine | These drugs are pyridoxine antagonists and can increase requirement/deficiency. | Moderate |
| Chloramphenicol | May antagonize the hematopoietic response to Vitamin B12. | Moderate |
| Proton Pump Inhibitors (Omeprazole, etc.), Metformin | Long-term use can impair B12 absorption, potentially increasing requirement. | Moderate |
| 5-Fluorouracil | May antagonize the effect of Thiamine. | Moderate |
Same composition (Thiamine(Vitamin B1) (100mg) + Vitamin B6 (Pyridoxine) (1000mcg) + Methylcobalamin (50mg)), different brands: