A fixed-dose combination topical preparation containing a corticosteroid (Beclometasone), an aminoglycoside antibiotic (Neomycin), and an imidazole antifungal (Clotrimazole). It is primarily indicated for the treatment of mixed dermatological infections where inflammation, bacterial, and fungal components coexist, commonly seen in tropical climates like India. It provides symptomatic relief from itching, redness, and scaling.
Adult: Apply a thin layer to the affected area 2 to 3 times daily, or as directed by the physician. Treatment should not exceed 2-4 weeks continuously.
Note: 1. Wash and dry the affected area gently. 2. Take a small amount of cream/ointment on a clean fingertip. 3. Apply a thin, even film and rub in gently. 4. Wash hands before and after application, unless hands are the treatment site. 5. Do not cover with occlusive dressings unless specifically advised. 6. Do not use in or near the eyes.
This combination exerts a triple action: 1) Anti-inflammatory & Immunosuppressive (Beclometasone), 2) Bactericidal (Neomycin), and 3) Fungistatic/Fungicidal (Clotrimazole). It targets the key pathological triad in infected dermatoses.
Pregnancy: Category C (US FDA). Topical corticosteroids, including beclometasone, should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Use the minimum effective dose for the shortest duration. Avoid large areas or long-term use.
Driving: No effect on driving ability.
| Other Topical Corticosteroids | Additive risk of local and systemic steroid adverse effects. | Major |
| Other Aminoglycosides (e.g., Gentamicin, systemic) | Increased risk of ototoxicity and nephrotoxicity. | Major |
| Loop Diuretics (e.g., Furosemide) | Potentiates neomycin ototoxicity. | Moderate |
| Neuromuscular Blocking Agents | Neomycin may potentiate neuromuscular blockade. | Moderate |
| CYP3A4 Inhibitors (e.g., Ketoconazole, Itraconazole, Clarithromycin) | May increase systemic levels of beclometasone, increasing steroid side effects. | Moderate |
Same composition (Beclometasone (0.025% w/v) + Neomycin (0.5% w/v) + Clotrimazole (1% w/v)), different brands: