A fixed-dose combination (FDC) of essential fat-soluble and water-soluble vitamins (A, D3, B1, B2, B5) formulated for the prevention and treatment of multiple vitamin deficiencies, particularly relevant in the Indian context where nutritional deficiencies are prevalent due to dietary habits, socioeconomic factors, and limited sun exposure. It supports immune function, energy metabolism, vision, bone health, and skin integrity.
Adult: One tablet/capsule once daily, or as directed by the physician. Preferably taken with a meal containing some fat to enhance absorption of Vitamins A and D3.
Note: Oral administration. Swallow whole with a glass of water. Take with or immediately after a meal to improve tolerance and absorption of fat-soluble vitamins. Do not crush or chew unless specified.
This combination acts by replenishing essential cofactors and signaling molecules for fundamental biochemical pathways. Vitamin A (as Retinol) is critical for phototransduction (rhodopsin), epithelial cell differentiation, and immune function. Thiamine (B1) is a coenzyme (TPP) for carbohydrate metabolism (pyruvate dehydrogenase, transketolase). Riboflavin (B2) is a precursor for FMN and FAD, coenzymes for redox reactions. Vitamin D3 regulates calcium/phosphate homeostasis, promotes bone mineralization, and modulates immune response via the Vitamin D Receptor (VDR). Pantothenic Acid (B5) is a component of Coenzyme A, essential for fatty acid oxidation and synthesis.
Pregnancy: Category A (at RDA levels). The Vitamin A dose (1000 mcg RE) is within the safe upper limit for pregnancy (≤3000 mcg RE). However, pregnant women should avoid additional Vitamin A supplements unless prescribed. Medical supervision is advised.
Driving: No known effects on driving ability.
| Isotretinoin / Oral Retinoids | Additive risk of Vitamin A toxicity and teratogenicity. | Major |
| Orlistat / Mineral Oil | Reduced absorption of fat-soluble vitamins (A, D). Administer at least 2 hours apart. | Moderate |
| Cholestyramine / Colestipol | Binds to fat-soluble vitamins, reducing their absorption. | Moderate |
| Phenytoin / Phenobarbital | May increase metabolism of Vitamin D, reducing its efficacy. | Moderate |
| Thiazide Diuretics | May increase risk of hypercalcemia when combined with Vitamin D. | Moderate |
| Alcohol (Chronic use) | Impairs absorption and activation of Thiamine (B1), increasing requirement. | Moderate |
Same composition (Vitamin A (1000mg) + Thiamine(Vitamin B1) (5mg) + Vitamin B2 (1.4mg) + Vitamin D3 (10mg) + Pantothenic Acid (Vitamin B5) (2.5mg)), different brands: