Hyaluronic Acid (HA) 0.20% w/w is a high molecular weight, viscoelastic polysaccharide, a key component of the extracellular matrix in skin and connective tissues. In topical ophthalmic and dermatological formulations, it acts as a lubricant, moisturizer, and viscoelastic protector. It is a non-sulfated glycosaminoglycan composed of repeating disaccharide units of D-glucuronic acid and N-acetyl-D-glucosamine. In the Indian market, it is widely used as an artificial tear substitute and a topical skin hydrator.
Adult: Ophthalmic: 1 drop in the affected eye(s), 3-4 times daily or as needed. Topical Skin: Apply a thin layer to clean, dry skin 1-2 times daily.
Note: Ophthalmic: Wash hands. Tilt head back, pull lower eyelid down, instill drop without touching tip. Close eye gently for 1-2 minutes. Topical: Apply to clean skin and massage gently until absorbed. For eyes: Remove contact lenses before application and wait 15 minutes before reinsertion.
Exogenously applied HA replicates the functions of endogenous HA. It binds and retains water molecules up to 1000 times its weight, creating a hydrated, viscoelastic matrix. In the eye, it lubricates, protects corneal epithelium, and stabilizes the tear film. On skin, it forms a hydrating film, improves skin barrier function, and modulates tissue repair.
Pregnancy: Category Not Assigned (Typically considered safe). Topical use is generally regarded as low risk due to minimal absorption. Use if clearly needed.
Driving: Caution advised immediately after ophthalmic application due to potential transient blurred vision. Wait until clear vision is restored.
| Other topical ophthalmic medications | Physical incompatibility or dilution. Instill at least 5-10 minutes apart. | Moderate |
| Topical corticosteroids or immunosuppressants (on skin) | HA may enhance penetration; monitor for increased effects/side effects of the other drug. | Low |
Same composition (Hyaluronic Acid (0.20% w/w)), different brands: