A co-formulated oral suspension combining Magaldrate, a balanced co-precipitate of aluminum and magnesium hydroxides (hydrotalcite), and Simethicone, an anti-foaming agent. Magaldrate acts as a potent, rapid-acting antacid with mucosal protective properties, while Simethicone reduces gas-related discomfort by lowering surface tension of gas bubbles. This combination is widely used in India for symptomatic relief of hyperacidity and associated bloating.
Adult: 10-20 ml (2-4 teaspoonfuls) orally, 4 times a day, preferably 20-60 minutes after meals and at bedtime, or as needed. Maximum 80 ml/day.
Note: Shake the bottle well before use. Use the measuring cup/spoon provided. Can be taken with or without water. For optimal effect, take 20-60 minutes after meals and at bedtime. Do not take other oral medications within 1-2 hours of this antacid.
Magaldrate neutralizes gastric hydrochloric acid, raising intragastric pH. It also adsorbs pepsin and bile salts, and stimulates prostaglandin synthesis and mucus secretion, offering mucosal protection. Simethicone is a surfactant that reduces the surface tension of gas bubbles in the GI tract, causing them to coalesce. This allows for easier elimination via belching or flatus, relieving bloating and discomfort.
Pregnancy: Category B (US FDA). Magaldrate and Simethicone are considered safe for occasional, short-term use during pregnancy as they are minimally absorbed. However, prolonged high-dose use of magaldrate should be avoided. Consult a physician.
Driving: No known effects. Safe.
| Tetracyclines (Doxycycline), Fluoroquinolones (Ciprofloxacin) | Decreased absorption due to chelation by aluminum/magnesium ions | Major |
| Iron supplements, Levothyroxine | Decreased absorption; separate administration by at least 2-4 hours | Moderate |
| Digoxin | Altered absorption; monitor digoxin levels | Moderate |
| Ketoconazole, Itraconazole | Reduced absorption due to increased gastric pH | Major |
| ACE Inhibitors (e.g., Ramipril) | May reduce efficacy; separate dosing | Moderate |
| Phosphate supplements | Aluminum binds phosphate, reducing its absorption | Moderate |
| Sodium Polystyrene Sulfonate | Risk of intestinal obstruction or metabolic alkalosis | Major |
Same composition (Magaldrate (400mg/5ml) + Simethicone (60mg/5ml)), different brands: